Pathway Publications

News & Updates

Pathway Publications

Original Publications

  1. Dennis, M. D., Coleman, C. S., Berg, A., Jefferson, L. S., & Kimball, S. R. (2014). REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling. Science Signaling, 7(335), ra68. https://doi.org/10.1126/scisignal.2005103
  2. Dennis, M. D., Kimball, S. R., Fort, P. E., & Jefferson, L. S. (2015). Regulated in development and DNA damage 1 is necessary for hyperglycemia-induced vascular endothelial growth factor expression in the retina of diabetic rodents. The Journal of Biological Chemistry, 290(6), 3865–3874. https://doi.org/10.1074/jbc.M114.623058
  3. Quang, D. X., Erdos, M. R., Parker, S. C. J., & Collins, F. S. (2015). Motif signatures in stretch enhancers are enriched for disease-associated genetic variants. Epigenetics & Chromatin, 8, 23. https://doi.org/10.1186/s13072-015-0015-7
  4. Krishnan, N., Krishnan, K., Connors, C. R., Choy, M. S., Page, R., Peti, W., … Tonks, N. K. (2015). PTP1B inhibition suggests a therapeutic strategy for Rett syndrome. The Journal of Clinical Investigation, 125(8), 3163–3177. https://doi.org/10.1172/JCI80323
  5. Krishnan, N., Koveal, D., Miller, D. H., Xue, B., Akshinthala, S. D., Kragelj, J., … Tonks, N. K. (2014). Targeting the disordered C terminus of PTP1B with an allosteric inhibitor. Nature Chemical Biology, 10(7), 558–566. https://doi.org/10.1038/nchembio.1528
  6. Yu, J., Zhang, Y., Ye, Y., DiSanto, R., Sun, W., Ranson, D., … Gu, Z. (2015). Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery. Proceedings of the National Academy of Sciences of the United States of America, 112(27), 8260–8265. https://doi.org/10.1073/pnas.1505405112
  7. Di, J., Yao, S., Ye, Y., Cui, Z., Yu, J., Ghosh, T. K., … Gu, Z. (2015). Stretch-Triggered Drug Delivery from Wearable Elastomer Films Containing Therapeutic Depots. ACS Nano, 9(9), 9407–9415. https://doi.org/10.1021/acsnano.5b03975
  8. Di, J., Yu, J., Ye, Y., Ranson, D., Jindal, A., Gu, Z. Engineering Synthetic Insulin-Secreting Cells Using Hyaluronic Acid Microgels Integrated with Glucose-Responsive Nanoparticles. Cellular and Molecular Bioengineering. 2015 (Cover Feature; Young Innovators Special Issue).
  9. Gao, M., Nguyen, T. T., Suckow, M. A., Wolter, W. R., Gooyit, M., Mobashery, S., & Chang, M. (2015). Acceleration of diabetic wound healing using a novel protease-anti-protease combination therapy. Proceedings of the National Academy of Sciences of the United States of America, 112(49), 15226–15231. https://doi.org/10.1073/pnas.1517847112
  10. Moore, J. A., Miller, W. P., & Dennis, M. D. (2016). Glucosamine induces REDD1 to suppress insulin action in retinal Müller cells. Cellular Signalling, 28(5), 384–390. https://doi.org/10.1016/j.cellsig.2016.01.017
  11. Delong, T., Wiles, T. A., Baker, R. L., Bradley, B., Barbour, G., Reisdorph, R., … Haskins, K. (2016). Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion. Science (New York, N.Y.), 351(6274), 711–714. https://doi.org/10.1126/science.aad2791
  12. Miller, W. P., Mihailescu, M. L., Yang, C., Barber, A. J., Kimball, S. R., Jefferson, L. S., & Dennis, M. D. (2016). The Translational Repressor 4E-BP1 Contributes to Diabetes-Induced Visual Dysfunction. Investigative Ophthalmology & Visual Science, 57(3), 1327–1337. https://doi.org/10.1167/iovs.15-18719
  13. Soares, M. A., Cohen, O. D., Low, Y. C., Sartor, R. A., Ellison, T., Anil, U., … Ceradini, D. J. (2016). Restoration of Nrf2 Signaling Normalizes the Regenerative Niche. Diabetes, 65(3), 633–646. https://doi.org/10.2337/db15-0453
  14. Ye, Y., Yu, J., Wang, C., Nguyen, N.-Y., Walker, G. M., Buse, J. B., & Gu, Z. (2016). Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery. Advanced Materials (Deerfield Beach, Fla.), 28(16), 3115–3121. https://doi.org/10.1002/adma.201506025
  15. Szodoray, P., Stanford, S. M., Molberg, Ø., Munthe, L. A., Bottini, N., & Nakken, B. (2016). T-helper signals restore B-cell receptor signaling in autoreactive anergic B cells by upregulating CD45 phosphatase activity. The Journal of Allergy and Clinical Immunology, 138(3), 839-851.e8. https://doi.org/10.1016/j.jaci.2016.01.035
  16. Scott, L. J., Erdos, M. R., Huyghe, J. R., Welch, R. P., Beck, A. T., Wolford, B. N., … Parker, S. C. J. (2016). The genetic regulatory signature of type 2 diabetes in human skeletal muscle. Nature Communications, 7, 11764. https://doi.org/10.1038/ncomms11764
  17. Powe, C. E., Allard, C., Battista, M.-C., Doyon, M., Bouchard, L., Ecker, J. L., … Hivert, M.-F. (2016). Heterogeneous Contribution of Insulin Sensitivity and Secretion Defects to Gestational Diabetes Mellitus. Diabetes Care, 39(6), 1052–1055. https://doi.org/10.2337/dc15-2672
  18. White, P. J., Lapworth, A. L., An, J., Wang, L., McGarrah, R. W., Stevens, R. D., … Newgard, C. B. (2016). Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export. Molecular Metabolism, 5(7), 538–551. https://doi.org/10.1016/j.molmet.2016.04.006
  19. Tang, J. C., Drokhlyansky, E., Etemad, B., Rudolph, S., Guo, B., Wang, S., … Cepko, C. L. (2016). Detection and manipulation of live antigen-expressing cells using conditionally stable nanobodies. ELife, 5. https://doi.org/10.7554/eLife.15312
  20. Peck, B. C. E., Sincavage, J., Feinstein, S., Mah, A. T., Simmons, J. G., Lund, P. K., & Sethupathy, P. (2016). miR-30 Family Controls Proliferation and Differentiation of Intestinal Epithelial Cell Models by Directing a Broad Gene Expression Program That Includes SOX9 and the Ubiquitin Ligase Pathway. The Journal of Biological Chemistry, 291(31), 15975–15984. https://doi.org/10.1074/jbc.M116.733733
  21. Zimmerman, C. A., Lin, Y.-C., Leib, D. E., Guo, L., Huey, E. L., Daly, G. E., … Knight, Z. A. (2016). Thirst neurons anticipate the homeostatic consequences of eating and drinking. Nature, 537(7622), 680–684. https://doi.org/10.1038/nature18950
  22. Fuchsberger, C., Flannick, J., Teslovich, T. M., Mahajan, A., Agarwala, V., Gaulton, K. J., … McCarthy, M. I. (2016). The genetic architecture of type 2 diabetes. Nature, 536(7614), 41–47. https://doi.org/10.1038/nature18642
  23. Leib, D. E., & Knight, Z. A. (2016). Rapid Sensing of Dietary Amino Acid Deficiency Does Not Require GCN2. Cell Reports, 16(8), 2051–2052. https://doi.org/10.1016/j.celrep.2016.08.022
  24. Chen, Y., Lin, Y.-C., Zimmerman, C. A., Essner, R. A., & Knight, Z. A. (2016). Hunger neurons drive feeding through a sustained, positive reinforcement signal. ELife, 5. https://doi.org/10.7554/eLife.18640
  25. Kimball, S. R., Gordon, B. S., Moyer, J. E., Dennis, M. D., & Jefferson, L. S. (2016). Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation. Cellular Signalling, 28(8), 896–906. https://doi.org/10.1016/j.cellsig.2016.03.008
  26. Kim, H.-E., Grant, A. R., Simic, M. S., Kohnz, R. A., Nomura, D. K., Durieux, J., … Dillin, A. (2016). Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response. Cell, 166(6), 1539-1552.e16. https://doi.org/10.1016/j.cell.2016.08.027
  27. Tan, C. L., Cooke, E. K., Leib, D. E., Lin, Y.-C., Daly, G. E., Zimmerman, C. A., & Knight, Z. A. (2016). Warm-Sensitive Neurons that Control Body Temperature. Cell, 167(1), 47-59.e15. https://doi.org/10.1016/j.cell.2016.08.028
  28. Gwiazda, K. S., Grier, A. E., Sahni, J., Burleigh, S. M., Martin, U., Yang, J. G., … Scharenberg, A. M. (2016). High Efficiency CRISPR/Cas9-mediated Gene Editing in Primary Human T-cells Using Mutant Adenoviral E4orf6/E1b55k “Helper” Proteins. Molecular Therapy: The Journal of the American Society of Gene Therapy, 24(9), 1570–1580. https://doi.org/10.1038/mt.2016.105
  29. Cardenas, A., Allard, C., Doyon, M., Houseman, E. A., Bakulski, K. M., Perron, P., … Hivert, M.-F. (2016). Validation of a DNA methylation reference panel for the estimation of nucleated cells types in cord blood. Epigenetics, 11(11), 773–779.
  30. Babon, J. A. B., DeNicola, M. E., Blodgett, D. M., Crèvecoeur, I., Buttrick, T. S., Maehr, R., … Kent, S. C. (2016). Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes. Nature Medicine, 22(12), 1482–1487. https://doi.org/10.1038/nm.4203
  31. Cardenas, A., Allard, C., Doyon, M., Houseman, E. A., Bakulski, K. M., Perron, P., … Hivert, M.-F. (2016). Validation of a DNA methylation reference panel for the estimation of nucleated cells types in cord blood. Epigenetics, 11(11), 773–779. https://doi.org/10.1080/15592294.2016.1233091
  32. Black, A. J., Gordon, B. S., Dennis, M. D., Jefferson, L. S., & Kimball, S. R. (2016). Regulation of protein and mRNA expression of the mTORC1 repressor REDD1 in response to leucine and serum. Biochemistry and Biophysics Reports, 8, 296–301. https://doi.org/10.1016/j.bbrep.2016.10.003
  33. Patenaude, J., Lacerte, G., Lacroix, M., Guillemette, L., Allard, C., Doyon, M., … Hivert, M.-F. (2017). Associations of Maternal Leptin with Neonatal Adiposity Differ according to Pregravid Weight. Neonatology, 111(4), 344–352. https://doi.org/10.1159/000454756
  34. Hu, X., Yu, J., Qian, C., Lu, Y., Kahkoska, A. R., Xie, Z., … Gu, Z. (2017). H2O2-Responsive Vesicles Integrated with Transcutaneous Patches for Glucose-Mediated Insulin Delivery. ACS Nano, 11(1), 613–620. https://doi.org/10.1021/acsnano.6b06892
  35. Douglass, J. D., Dorfman, M. D., Fasnacht, R., Shaffer, L. D., & Thaler, J. P. (2017). Astrocyte IKKβ/NF-κB signaling is required for diet-induced obesity and hypothalamic inflammation. Molecular Metabolism, 6(4), 366–373. https://doi.org/10.1016/j.molmet.2017.01.010
  36. Miller, W. P., Ravi, S., Martin, T. D., Kimball, S. R., & Dennis, M. D. (2017). Activation of the Stress Response Kinase JNK (c-Jun N-terminal Kinase) Attenuates Insulin Action in Retina through a p70S6K1-dependent Mechanism. The Journal of Biological Chemistry, 292(5), 1591–1602. https://doi.org/10.1074/jbc.M116.760868
  37. Choy, M. S., Li, Y., Machado, L. E. S. F., Kunze, M. B. A., Connors, C. R., Wei, X., … Peti, W. (2017). Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Molecular Cell, 65(4), 644-658.e5. https://doi.org/10.1016/j.molcel.2017.01.014
  38. Peck, B. C. E., Mah, A. T., Pitman, W. A., Ding, S., Lund, P. K., & Sethupathy, P. (2017). Functional Transcriptomics in Diverse Intestinal Epithelial Cell Types Reveals Robust MicroRNA Sensitivity in Intestinal Stem Cells to Microbial Status. The Journal of Biological Chemistry, 292(7), 2586–2600. https://doi.org/10.1074/jbc.M116.770099
  39. Dorfman, M. D., Krull, J. E., Douglass, J. D., Fasnacht, R., Lara-Lince, F., Meek, T. H., … Thaler, J. P. (2017). Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice. Nature Communications, 8, 14556. https://doi.org/10.1038/ncomms14556
  40. Varshney, A., Scott, L. J., Welch, R. P., Erdos, M. R., Chines, P. S., Narisu, N., … Stitzel, M. L. (2017). Genetic regulatory signatures underlying islet gene expression and type 2 diabetes. Proceedings of the National Academy of Sciences of the United States of America, 114(9), 2301–2306. https://doi.org/10.1073/pnas.1621192114
  41. Wiles, T. A., Delong, T., Baker, R. L., Bradley, B., Barbour, G., Powell, R. L., … Haskins, K. (2017). An insulin-IAPP hybrid peptide is an endogenous antigen for CD4 T cells in the non-obese diabetic mouse. Journal of Autoimmunity, 78, 11–18. https://doi.org/10.1016/j.jaut.2016.10.007
  42. Dorfman, M. D., Krull, J. E., Scarlett, J. M., Guyenet, S. J., Sajan, M. P., Damian, V., … Thaler, J. P. (2017). Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity. Diabetes, 66(4), 920–934. https://doi.org/10.2337/db16-0482
  43. Machado, L. E. S. F., Shen, T.-L., Page, R., & Peti, W. (2017). The KIM-family protein-tyrosine phosphatases use distinct reversible oxidation intermediates: Intramolecular or intermolecular disulfide bond formation. The Journal of Biological Chemistry, 292(21), 8786–8796. https://doi.org/10.1074/jbc.M116.774174
  44. Wang, C., Ye, Y., Sun, W., Yu, J., Wang, J., Lawrence, D. S., … Gu, Z. (2017). Red Blood Cells for Glucose-Responsive Insulin Delivery. Advanced Materials (Deerfield Beach, Fla.), 29(18). https://doi.org/10.1002/adma.201606617
  45. Hivert, M.-F., Scholtens, D. M., Allard, C., Nodzenski, M., Bouchard, L., Brisson, D., … Lowe, W. L. (2017). Genetic determinants of adiponectin regulation revealed by pregnancy. Obesity (Silver Spring, Md.), 25(5), 935–944. https://doi.org/10.1002/oby.21805
  46. Stanford, S. M., Aleshin, A. E., Zhang, V., Ardecky, R. J., Hedrick, M. P., Zou, J., … Bottini, N. (2017). Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nature Chemical Biology, 13(6), 624–632. https://doi.org/10.1038/nchembio.2344
  47. Rabbani, P. S., Zhou, A., Borab, Z. M., Frezzo, J. A., Srivastava, N., More, H. T., … Ceradini, D. J. (2017). Novel lipoproteoplex delivers Keap1 siRNA based gene therapy to accelerate diabetic wound healing. Biomaterials, 132, 1–15. https://doi.org/10.1016/j.biomaterials.2017.04.001
  48. Pereira, M. M. A., Mahú, I., Seixas, E., Martinéz-Sánchez, N., Kubasova, N., Pirzgalska, R. M., … Domingos, A. I. (2017). A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages. Nature Communications, 8, 14967. https://doi.org/10.1038/ncomms14967
  49. Valdearcos, M., Douglass, J. D., Robblee, M. M., Dorfman, M. D., Stifler, D. R., Bennett, M. L., … Koliwad, S. K. (2017). Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility. Cell Metabolism, 26(1), 185-197.e3. https://doi.org/10.1016/j.cmet.2017.05.015
  50. Riera, C. E., Tsaousidou, E., Halloran, J., Follett, P., Hahn, O., Pereira, M. M. A., … Dillin, A. (2017). The Sense of Smell Impacts Metabolic Health and Obesity. Cell Metabolism, 26(1), 198-211.e5. https://doi.org/10.1016/j.cmet.2017.06.015
  51. Flak, J. N., Arble, D., Pan, W., Patterson, C., Lanigan, T., Goforth, P. B., … Myers, M. G. (2017). A leptin-regulated circuit controls glucose mobilization during noxious stimuli. The Journal of Clinical Investigation, 127(8), 3103–3113. https://doi.org/10.1172/JCI90147
  52. Wheeler, E., Leong, A., Liu, C.-T., Hivert, M.-F., Strawbridge, R. J., Podmore, C., … Meigs, J. B. (2017). Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis. PLoS Medicine, 14(9), e1002383. https://doi.org/10.1371/journal.pmed.1002383
  53. Yan, X., Wang, Z., Westberg-Rasmussen, S., Tarbier, M., Rathjen, T., Tattikota, S. G., … Poy, M. N. (2017). Differential Impact of Glucose Administered Intravenously and Orally on Circulating miR-375 Levels in Human Subjects. The Journal of Clinical Endocrinology and Metabolism, 102(10), 3749–3755. https://doi.org/10.1210/jc.2017-01365
  54. Sharp, G. C., Salas, L. A., Monnereau, C., Allard, C., Yousefi, P., Everson, T. M., … Relton, C. L. (2017). Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium. Human Molecular Genetics, 26(20), 4067–4085. https://doi.org/10.1093/hmg/ddx290
  55. Beutler, L. R., Chen, Y., Ahn, J. S., Lin, Y.-C., Essner, R. A., & Knight, Z. A. (2017). Dynamics of Gut-Brain Communication Underlying Hunger. Neuron, 96(2), 461-475.e5. https://doi.org/10.1016/j.neuron.2017.09.043
  56. Choy, M. S., Swingle, M., D’Arcy, B., Abney, K., Rusin, S. F., Kettenbach, A. N., … Peti, W. (2017). PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors. Journal of the American Chemical Society, 139(49), 17703–17706. https://doi.org/10.1021/jacs.7b09368
  57. Flannick, J., Fuchsberger, C., Mahajan, A., Teslovich, T. M., Agarwala, V., Gaulton, K. J., … McCarthy, M. I. (2017). Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data, 4, 170179. https://doi.org/10.1038/sdata.2017.179
  58. Machado, L. E. S. F., Page, R., & Peti, W. (2018). 1H, 15N and 13C sequence specific backbone assignment of the vanadate inhibited hematopoietic tyrosine phosphatase. Biomolecular NMR Assignments, 12(1), 5–9. https://doi.org/10.1007/s12104-017-9770-7
  59. Miller, W. P., Yang, C., Mihailescu, M. L., Moore, J. A., Dai, W., Barber, A. J., & Dennis, M. D. (2018). Deletion of the Akt/mTORC1 Repressor REDD1 Prevents Visual Dysfunction in a Rodent Model of Type 1 Diabetes. Diabetes, 67(1), 110–119. https://doi.org/10.2337/db17-0728
  60. Zillikens, M. C., Demissie, S., Hsu, Y.-H., Yerges-Armstrong, L. M., Chou, W.-C., Stolk, L., … Kiel, D. P. (2017). Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. Nature Communications, 8(1), 80. https://doi.org/10.1038/s41467-017-00031-7
  61. Roman, T. S., Cannon, M. E., Vadlamudi, S., Buchkovich, M. L., Wolford, B. N., Welch, R. P., … Mohlke, K. L. (2017). A Type 2 Diabetes-Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the ADCY5 Locus. Diabetes, 66(9), 2521–2530. https://doi.org/10.2337/db17-0464
  62. Leib, D. E., Zimmerman, C. A., Poormoghaddam, A., Huey, E. L., Ahn, J. S., Lin, Y.-C., … Knight, Z. A. (2017). The Forebrain Thirst Circuit Drives Drinking through Negative Reinforcement. Neuron, 96(6), 1272-1281.e4. https://doi.org/10.1016/j.neuron.2017.11.041
  63. Chen, Z., Wang, J., Sun, W., Archibong, E., Kahkoska, A. R., Zhang, X., … Gu, Z. (2018). Synthetic beta cells for fusion-mediated dynamic insulin secretion. Nature Chemical Biology, 14(1), 86–93. https://doi.org/10.1038/nchembio.2511
  64. Nguyen, T. T., Ding, D., Wolter, W. R., Champion, M. M., Hesek, D., Lee, M., … Chang, M. (2018). Expression of active matrix metalloproteinase-9 as a likely contributor to the clinical failure of aclerastide in treatment of diabetic foot ulcers. European Journal of Pharmacology, 834, 77–83. https://doi.org/10.1016/j.ejphar.2018.07.014
  65. White, P. J., McGarrah, R. W., Grimsrud, P. A., Tso, S.-C., Yang, W.-H., Haldeman, J. M., … Newgard, C. B. (2018). The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase. Cell Metabolism, 27(6), 1281-1293.e7. https://doi.org/10.1016/j.cmet.2018.04.015
  66. Rabbani, P. S., Ellison, T., Waqas, B., Sultan, D., Abdou, S., David, J. A., … Ceradini, D. J. (2018). Targeted Nrf2 activation therapy with RTA 408 enhances regenerative capacity of diabetic wounds. Diabetes Research and Clinical Practice, 139, 11–23. https://doi.org/10.1016/j.diabres.2018.02.021
  67. Fang, C., Zhong, H., Lin, Y., Chen, B., Han, M., Ren, H., … Li, J. (2018). Assessment of the cPAS-based BGISEQ-500 platform for metagenomic sequencing. GigaScience, 7(3), 1–8. https://doi.org/10.1093/gigascience/gix133
  68. Luber, J. M., Tierney, B. T., Cofer, E. M., Patel, C. J., & Kostic, A. D. (2018). Aether: leveraging linear programming for optimal cloud computing in genomics. Bioinformatics (Oxford, England), 34(9), 1565–1567. https://doi.org/10.1093/bioinformatics/btx787
  69. Pan, W., Adams, J. M., Allison, M. B., Patterson, C., Flak, J. N., Jones, J., … Myers, M. G. (2018). Essential Role for Hypothalamic Calcitonin Receptor‒Expressing Neurons in the Control of Food Intake by Leptin. Endocrinology, 159(4), 1860–1872. https://doi.org/10.1210/en.2017-03259
  70. Meek, T. H., Matsen, M. E., Faber, C. L., Samstag, C. L., Damian, V., Nguyen, H. T., … Morton, G. J. (2018). In Uncontrolled Diabetes, Hyperglucagonemia and Ketosis Result From Deficient Leptin Action in the Parabrachial Nucleus. Endocrinology, 159(4), 1585–1594. https://doi.org/10.1210/en.2017-03199
  71. Kycia, I., Wolford, B. N., Huyghe, J. R., Fuchsberger, C., Vadlamudi, S., Kursawe, R., … Stitzel, M. L. (2018). A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression. American Journal of Human Genetics, 102(4), 620–635. https://doi.org/10.1016/j.ajhg.2018.02.020
  72. Dai, W., Dierschke, S. K., Toro, A. L., & Dennis, M. D. (2018). Consumption of a high fat diet promotes protein O-GlcNAcylation in mouse retina via NR4A1-dependent GFAT2 expression. Biochimica Et Biophysica Acta. Molecular Basis of Disease, 1864(12), 3568–3576. https://doi.org/10.1016/j.bbadis.2018.09.006
  73. Dai, W., Miller, W. P., Toro, A. L., Black, A. J., Dierschke, S. K., Feehan, R. P., … Dennis, M. D. (2018). Deletion of the stress-response protein REDD1 promotes ceramide-induced retinal cell death and JNK activation. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, fj201800413RR. https://doi.org/10.1096/fj.201800413RR
  74. Taylor, D. L., Knowles, D. A., Scott, L. J., Ramirez, A. H., Casale, F. P., Wolford, B. N., … Collins, F. S. (2018). Interactions between genetic variation and cellular environment in skeletal muscle gene expression. PloS One, 13(4), e0195788. https://doi.org/10.1371/journal.pone.0195788
  75. Zou, L. S., Erdos, M. R., Taylor, D. L., Chines, P. S., Varshney, A., McDonnell Genome Institute, … Didion, J. P. (2018). BoostMe accurately predicts DNA methylation values in whole-genome bisulfite sequencing of multiple human tissues. BMC Genomics, 19(1), 390. https://doi.org/10.1186/s12864-018-4766-y
  76. Orchard, P., White, J. S., Thomas, P. E., Mychalowych, A., Kiseleva, A., Hensley, J., … Keegan, C. E. (2018). Genome-wide chromatin accessibility and transcriptome profiling show minimal epigenome changes and coordinated transcriptional dysregulation of hedgehog signaling in Danforth’s short tail mice. Human Molecular Genetics. https://doi.org/10.1093/hmg/ddy378
  77. Powe, C. E., Nodzenski, M., Talbot, O., Allard, C., Briggs, C., Leya, M. V., … Hivert, M.-F. (2018). Genetic Determinants of Glycemic Traits and the Risk of Gestational Diabetes Mellitus. Diabetes. https://doi.org/10.2337/db18-0203
  78. Cardenas, A., Gagné-Ouellet, V., Allard, C., Brisson, D., Perron, P., Bouchard, L., & Hivert, M.-F. (2018). Placental DNA Methylation Adaptation to Maternal Glycemic Response in Pregnancy. Diabetes, 67(8), 1673–1683. https://doi.org/10.2337/db18-0123
  79. Keith, B. P., Barrow, J. B., Toyonaga, T., Kazgan, N., O’Connor, M. H., Shah, N. D., … Sheikh, S. Z. (2018). Colonic epithelial miR-31 associates with the development of Crohn’s phenotypes. JCI Insight, 3(19). https://doi.org/10.1172/jci.insight.122788
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